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Progressive Multifocal Leukoencephalopathy (PML) Category: disease

Progressive Multifocal Leukoencephalopathy (PML) = viral infection caused by JC-virus (papovagroup)

sympt: slowly progressive, focal neurology, sometimes seizures, no headache or fever
CT: multiple hypodensities in white matter without contrast enhancement or space occupying effect
MRI: specific hyperintense white matter abormalities (T2)
LP: normal
PA: demyelinisation, abnormal oligodendrocytes, JC-virus
ther: experimental: cytarabine 2 mg/kg/dd iv during 5 days
course: median survival 4 months

Last modified: 2007-11-21 Level: physician Article visits: 3337
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